rituximab-pvvr 投稿者：Roma 投稿日：2026/03/11(Wed) 11:54 No.17181829 
Extreme and life-threatening thrombocytopenia has been reported throughout therapy with GAZYVA together with chemotherapy. Monitor all patients regularly for thrombocytopenia and hemorrhagic occasions, particularly throughout the primary cycle and if clinically indicated, consider laboratory coagulation parameters. In patients with Grade three or four thrombocytopenia, monitor platelet counts extra incessantly till decision and consider dose delays of GAZYVA and chemotherapy or dose reductions of chemotherapy. Transfusion of blood merchandise (i.e., platelet transfusion) could also be crucial. Fatal and extreme DIC has been reported in patients receiving GAZYVA for therapy of follicular lymphoma and chronic lymphocytic leukemia. The vast majority of DIC circumstances have concerned adjustments in platelets and laboratory coagulation parameters following the primary infusion, with spontaneous decision normally occurring by Day 8. In some instances, DIC was related to IRRs, TLS, or each. In patients with suspected DIC, consider potential causes, and monitor coagulation parameters, platelet counts, and for indicators and signs of bleeding or thrombosis. Handle in accordance to straightforward tips for DIC.
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