contraceptive implant 投稿者：Marylou 投稿日：2026/01/10(Sat) 10:47 No.17121997 
Detection of signaling adjustments in response to rituximab typically requires cross-linking of the rituximab with secondary antibodies. The affinity of anti-rituximab antibodies for rituximab is way increased than the affinity of rituximab Fc for FcR, and there's appreciable cross-linking due to the bivalent nature of the cross-linking IgG. This artificially enhances the energy of the sign. It's not clear whether or not cross-linking of rituximab serves to hurry up and strengthen the physiological impact of rituximab signaling so it may be measured in a brief assay, or supplies such a robust sign that non-physiologic modifications are induced that will not be related clinically. Pattern processing itself induces signaling modifications, making the research of signaling in main lymphoma samples extraordinarily troublesome. To keep away from this predicament, most signaling assays contain use of cell traces that are very totally different from main malignant cells. In vitro synergy between rituximab and cytotoxic chemotherapy has been demonstrated (13). Clones grown to be resistant to rituximab in vitro additionally present resistance to cytotoxic chemotherapy suggesting frequent mechanisms could also be at play (14). Vega and colleagues just lately demonstrated that each intact rituximab and modified rituximab, that now not fixes complement or mediates ADCC, inhibit the exercise of cell survival/progress together with those who regulate drug resistance.
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